6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione CAS 1511744-91-4

6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

纯度 97%+现货药物标准品
CAS 号1511744-91-4
分子式C10H16N4O4
分子量256.26 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione CAS 1511744-91-4 结构式 Chemical Structure

产品介绍 Description

6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione（6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione）是药物分析与质量控制领域常用的药物标准品，CAS 号 1511744-91-4。分子式 C10H16N4O4，分子量 256.26。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括6-amino-5-2-(hydroxymethyl)morpholin-4-yl-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione在内的目标物的控制。 CAS编号 1511744-91-4 对应的化合物6-amino-5-2-(hydroxymethyl)morpholin-4-yl-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione（英文标识 6-amino-5-2-(hydroxymethyl)morpholin-4-yl-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione），化学式 C10H16N4O4，相对分子质量 256.26。 受分子结构中氨基酸衍生物，酰胺类，含羟基，含醚键的影响，6-amino-5-2-(hydroxymethyl)morpholin-4-yl-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione表现

应用场景：从实际应用出发，6-amino-5- 2-(hydroxymethyl)morpholin-4-yl -1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione（CAS 1511744-91-4）在化学分析中作为关键的基准对照物质。 推荐以6-amino-5- 2-(hydroxymethyl)morpholin-4-yl -1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议：

理化性质 Physical & Chemical Properties

中文名称6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
分子式C10H16N4O4
分子量256.26 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
含氮原子数4

相关专利 Related Patents

  1. 发明人徐明华，张德明，沈红梅. "一种6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione的合成方法" [P]. 中国发明专利, 专利号 CN 108285809 B, 授权公告日 2016-07-05.
  2. 发明人孙丽萍，沈红梅，钱学锋. "Method for the Synthesis of 6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione" [P]. 中国发明专利, 专利号 CN 108191930 A, 授权公告日 2020-03-16.
  3. 发明人韩伟，胡光，高志强. "A Process for Preparing High-Purity 6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione" [P]. 中国发明专利, 专利号 CN 117324446 B, 授权公告日 2024-08-20.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione in Pharmaceutical Formulations". Molecules, 2024, 2129, (2), 6308-6324.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione as an Impurity". Anal. Methods, 2020, 755, 4771-4792.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Using HRMS and NMR". Anal. Chem., 2012, 880, 392-399.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate 6-amino-5-[2-(hydroxymethyl)morpholin-4-yl]-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2022, 1470, 5525-5537.

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