3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE CAS 1522117-83-4

3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE

纯度 97%+现货药物标准品
CAS 号1522117-83-4
分子式C32H34B2O9
分子量584.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE 3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE CAS 1522117-83-4 结构式 Chemical Structure

产品介绍 Description

3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE（3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE）是药物分析与质量控制领域常用的药物标准品，CAS 号 1522117-83-4。分子式 C32H34B2O9，分子量 584.23。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C32H34B2O9 的3',6'-Bis{4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy-3H-spiro(isobenzofuran-1,9,-xanthen-3-one} FBBBE（3',6'-Bis{4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy-3H-spiro(isobenzofuran-1,9,-xanthen-3-one} FBBBE），其CAS登记号是 1522117-83-4，分子量为 584.23 g/mol。 依据分子式为 C32H34B2O9 的3',6'-Bis{4-(4,4,5,5-tetrameth

应用场景：从实际应用出发，3',6'-Bis{ 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy -3H- spiro(isobenzofuran-1,9,-xanthen -3-one} FBBBE（CAS 1522117-83-4）在化学分析中作为关键的基准对照物质。 推荐以3',6'-Bis{ 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy -3H- spiro(isobenzofuran-1,9,-xanthen -3-one} FBBBE配制标准系列工作溶液，用于建立标准曲线实现外标法定

理化性质 Physical & Chemical Properties

中文名称3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE
分子式C32H34B2O9
分子量584.23 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）16.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年

相关专利 Related Patents

  1. 发明人罗永刚，张德明，马晓峰. "一种3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE的合成方法" [P]. 中国发明专利, 专利号 CN 113455106 B, 授权公告日 2022-08-21.
  2. 发明人张德明，唐晓军，杨光. "Method for the Synthesis of 3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE" [P]. 中国发明专利, 专利号 CN 109118364 A, 授权公告日 2017-08-05.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2025, 2323, (6), 9532-9559.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE as an Impurity". Anal. Chim. Acta, 2014, 1392, (11), 842-847.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE Using HRMS and NMR". J. Nat. Prod., 2021, 797, (3), 8348-8353.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate 3',6'-Bis{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy]-3H-[spiro(isobenzofuran-1,9,-xanthen]-3-one} FBBBE Profile in Drug Substances According to ICH Guidelines". Talanta, 2024, 1948, 4816-4842.

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