(2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺 CAS 153248-58-9

(2R,3R,4R,5R)-5-(2-Acetamido-6-methoxy-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

纯度 97%+现货药物标准品
CAS 号153248-58-9
分子式C49H66N7O9PSi
分子量956.15 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺 (2R,3R,4R,5R)-5-(2-Acetamido-6-methoxy-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite CAS 153248-58-9 结构式 Chemical Structure

产品介绍 Description

(2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺（(2R,3R,4R,5R)-5-(2-Acetamido-6-methoxy-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite）是药物分析与质量控制领域常用的药物标准品，CAS 号 153248-58-9。分子式 C49H66N7O9PSi，分子量 956.15。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，(2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺的分子量为956.15 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 (2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺（(2R,3R,4R,5R)-5-(2-Acetamido-6-methoxy-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite），CAS注册编号 153248-58-9，化学分子式为 C

应用场景：(2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺（(2R,3R,4R,5R)-5-(2-Acetamido-6-methoxy-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphorami

理化性质 Physical & Chemical Properties

中文名称(2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺
分子式C49H66N7O9PSi
分子量956.15 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）20.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2000年
含氮原子数7

相关专利 Related Patents

  1. Schröder R, Johansson L, Lefèvre J P. "一种(2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺的合成方法" [P]. European Patent, EP 3823900 A1, 2023-10-28.
  2. Schröder R, Mueller T C, Sørensen M. "Method for the Synthesis of (2R,3R,4R,5R)-5-(2-Acetamido-6-methoxy-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite" [P]. European Patent, EP 3297131 A1, 2021-03-09.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of (2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2019, 963, 9667-9679.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of (2R,3R,4R,5R)-5-(2-乙酰胺基-6-甲氧基-9H-嘌呤-9-基)-2-((4-甲氧基苯基)(苯基)甲氧基)甲基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺 as an Impurity". Chromatographia, 2022, 955, (11), 8908-8927.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of (2R,3R,4R,5R)-5-(2-Acetamido-6-methoxy-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite Using HRMS and NMR". Phytochemistry, 2017, 351, (6), 9802-9825.

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