1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride CAS 154474-91-6

1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride

纯度 97%+现货药物标准品
CAS 号154474-91-6
分子式C10H16N6 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride 1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride CAS 154474-91-6 结构式 Chemical Structure

产品介绍 Description

1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride（英文名 1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride，CAS 154474-91-6）属于药物标准品。分子式 C10H16N6 2*HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，1-(3-{(diaminomethylidene)aminomethyl}phenyl)methylguanidine dihydrochloride的分子量为256.74 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 1-(3-{(diaminomethylidene)aminomethyl}phenyl)methylguanidine dihydrochloride（1-(3-{(diaminomethylidene)aminomethyl}phenyl)methylguanidine dihydrochloride），CAS注册编号 154474-91-6，化学分子式为 C10H16N6 2HCl，分子量 256.74 g/mol。 1-(3-{(diaminomethylidene)aminomethyl}phenyl)methylguanidine dihydrochloride（C10H16N6 2HCl）含有含氮杂环结构，含氰基，含氯取代。卤素取代增加了化合物的密度和沸点，这些物理化学

应用场景：1- (3-{ (diaminomethylidene)amino methyl}phenyl)methyl guanidine dihydrochloride（1- (3-{ (diaminomethylidene)amino methyl}phenyl)methyl guanidine dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以1- (3-{ (diaminomethylidene)amino methyl}phenyl)methyl guanidine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。

理化性质 Physical & Chemical Properties

中文名称1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride
分子式C10H16N6 2*HCl
分子量256.74 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2001年
卤素含量Cl取代
含氮原子数6

相关专利 Related Patents

  1. Anderson J P, Yamamoto T, Schröder R. "一种1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride的合成方法" [P]. US Patent, US 10672829 B2, 2025-06-07.
  2. 发明人何建平，徐明华，黄志刚. "Method for the Synthesis of 1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride" [P]. 中国发明专利, 专利号 CN 110185514 A, 授权公告日 2016-09-10.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride in Pharmaceutical Formulations". J. Chromatogr. A, 2024, 305, (2), 2650-2665.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride as an Impurity". Molecules, 2015, 511, 8581-8602.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride Using HRMS and NMR". Anal. Methods, 2024, 2078, (5), 4179-4198.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate 1-[(3-{[(diaminomethylidene)amino]methyl}phenyl)methyl]guanidine dihydrochloride Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2022, 2065, (6), 5609-5616.

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