2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine CAS 1546544-78-8

2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine

纯度 97%+现货药物标准品
CAS 号1546544-78-8
分子式C15H20F4N2
分子量304.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine 2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine CAS 1546544-78-8 结构式 Chemical Structure

产品介绍 Description

2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine（2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine）是药物分析与质量控制领域常用的药物标准品，CAS 号 1546544-78-8。分子式 C15H20F4N2，分子量 304.33。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，2-(1-{4-fluoro-3-(trifluoromethyl)phenylmethyl}piperidin-3-yl)ethan-1-amine的分子量为304.33 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 2-(1-{4-fluoro-3-(trifluoromethyl)phenylmethyl}piperidin-3-yl)ethan-1-amine（2-(1-{4-fluoro-3-(trifluoromethyl)phenylmethyl}piperidin-3-yl)ethan-1-amine），CAS注册编号 1546544-78-8，化学分子式为 C15H20F4N2，分子量 304.33 g/mol。 2-(1-{4-fluoro-3-(trifluoromethyl)phenylmethyl}piperidin-3-yl)ethan-1-amine（分子式 C15H20F4N2）的化学结构中包含含氮杂环结构，含氰基，含氟取代。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响

应用场景：针对化学分析用途，2-(1-{ 4-fluoro-3-(trifluoromethyl)phenyl methyl}piperidin-3-yl)ethan-1-amine（2-(1-{ 4-fluoro-3-(trifluoromethyl)phenyl methyl}piperidin-3-yl)ethan-1-amine）是具有明确定量溯源的认证级对照品。 推荐以2-(1-{ 4-fluoro-3-(trifluoromethyl)phenyl methyl}piperidin-3-yl)ethan-1-amine配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶

理化性质 Physical & Chemical Properties

中文名称2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine
分子式C15H20F4N2
分子量304.33 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. Patel M V, Davis P L, Lee S K. "一种2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine的合成方法" [P]. US Patent, US 10847928 B2, 2021-08-03.
  2. 发明人沈红梅，朱建伟，钱学锋. "Method for the Synthesis of 2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine" [P]. 中国发明专利, 专利号 CN 117572698 B, 授权公告日 2015-11-23.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine in Pharmaceutical Formulations". Talanta, 2010, 2261, (7), 1743-1771.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine as an Impurity". Phytochemistry, 2024, 1469, (12), 4199-4207.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine Using HRMS and NMR". Molecules, 2023, 200, (3), 6565-6574.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate 2-(1-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)ethan-1-amine Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2018, 547, 3531-3559.

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