Hughes D C, Roberts E F, Park J H. "一种的合成方法" [P]. US Patent, US 10495164 B2, 2016-08-25.
发明人朱建伟,赵玉洁,张德明. "Method for the Synthesis of 155319-91-8
N02W67RKJS
Mangafodipir [INN:BAN]
Hexahydrogen(OC-6-13)-((N,N''-ethylenebis(N-((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridyl)methyl)glycine)5,5'-bis(phosphato))(8-)manganate(6-)
Manganate(6-), ((N,N'-1,2-ethanediylbis(N-((3-(hydroxy-kappaO)-2-methyl-5-((phosphonooxy)methyl)-4-pyridinyl)methyl)glycinato-kappaN,kappaO))(8-))-, hexahydrogen, (OC-6-13)-
Mangafodipir
Hexahydrogen (OC-6-13)-((N,N'-ethylenebis(N-((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridyl)methyl)glycine) 5,5'-bis(phosphato))(8-))manganate(6-)
UNII-N02W67RKJS" [P]. 中国发明专利, 专利号 CN 110655140 B, 授权公告日 2022-01-18.
发明人徐明华,李文辉,张德明. "A Process for Preparing High-Purity 155319-91-8
N02W67RKJS
Mangafodipir [INN:BAN]
Hexahydrogen(OC-6-13)-((N,N''-ethylenebis(N-((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridyl)methyl)glycine)5,5'-bis(phosphato))(8-)manganate(6-)
Manganate(6-), ((N,N'-1,2-ethanediylbis(N-((3-(hydroxy-kappaO)-2-methyl-5-((phosphonooxy)methyl)-4-pyridinyl)methyl)glycinato-kappaN,kappaO))(8-))-, hexahydrogen, (OC-6-13)-
Mangafodipir
Hexahydrogen (OC-6-13)-((N,N'-ethylenebis(N-((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridyl)methyl)glycine) 5,5'-bis(phosphato))(8-))manganate(6-)
UNII-N02W67RKJS" [P]. 中国发明专利, 专利号 CN 114324185 A, 授权公告日 2023-09-26.
参考文献 Literature
Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Phytochemistry, 2012, 2284, (12), 6649-6670.
Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chem., 2021, 1863, 8314-8321.
Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 155319-91-8
N02W67RKJS
Mangafodipir [INN:BAN]
Hexahydrogen(OC-6-13)-((N,N''-ethylenebis(N-((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridyl)methyl)glycine)5,5'-bis(phosphato))(8-)manganate(6-)
Manganate(6-), ((N,N'-1,2-ethanediylbis(N-((3-(hydroxy-kappaO)-2-methyl-5-((phosphonooxy)methyl)-4-pyridinyl)methyl)glycinato-kappaN,kappaO))(8-))-, hexahydrogen, (OC-6-13)-
Mangafodipir
Hexahydrogen (OC-6-13)-((N,N'-ethylenebis(N-((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridyl)methyl)glycine) 5,5'-bis(phosphato))(8-))manganate(6-)
UNII-N02W67RKJS Using HRMS and NMR". J. Chromatogr. A, 2017, 86, (3), 6703-6714.