2-[3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester CAS 1572503-72-0

Ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate

纯度 97%+现货药物标准品
CAS 号1572503-72-0
分子式C18H20N2O4S
分子量360.43 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-[3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester Ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate CAS 1572503-72-0 结构式 Chemical Structure

产品介绍 Description

CAS 1572503-72-0 对应的2-[3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester（Ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C18H20N2O4S，分子量 360.43。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester在内的目标物的控制。 化学式为 C18H20N2O4S 的2-3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester（Ethyl 2-3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl-4-methyl-1,3-thiazole-5-carboxylate），其CAS登记号是 1572503-72-0，分子量为 360.43 g/mol。 依据分子式为 C18H20N2O4S 的2-3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester结构特征

应用场景：2- 3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl -4-methyl-5-thiazolecarboxylic Acid Ethyl Ester（Ethyl 2- 3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl -4-methyl-1,3-thiazole-5-carboxylate，CAS 1572503-72-0）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以2- 3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl -4-methyl-5-thiazoleca

理化性质 Physical & Chemical Properties

中文名称2-[3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester
分子式C18H20N2O4S
分子量360.43 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1993年
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. O'Brien P Q, Mueller T, Hughes D C. "一种2-[3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester的合成方法" [P]. US Patent, US 10055345 B2, 2015-12-22.
  2. 发明人张德明，马晓峰，陈志强. "Method for the Synthesis of Ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate" [P]. 中国发明专利, 专利号 CN 110070457 B, 授权公告日 2017-07-23.
  3. 发明人刘建华，高志强，冯建国. "A Process for Preparing High-Purity Ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate" [P]. 中国发明专利, 专利号 CN 110593457 B, 授权公告日 2022-02-19.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 2-[3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester in Pharmaceutical Formulations". Molecules, 2010, 849, (4), 4252-4276.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-[3-Cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester as an Impurity". Chemosphere, 2024, 723, (11), 6634-6645.

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