N/A CAS 158792-27-9

Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-lactam

纯度 97%+现货药物标准品
CAS 号158792-27-9
分子式C50H49N15O15S
分子量1132.08 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N/A Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-lactam CAS 158792-27-9 结构式 Chemical Structure

产品介绍 Description

N/A（Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-lactam，CAS 号 158792-27-9）是 CATO 佳途自主生产的药物标准品，分子式 C50H49N15O15S，分子量 1132.08。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 N/A（Alaninamide, L-threonyl-2-(1Z)-1-amino-1-propen-1-yl-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-2-(1-aminoethenyl)-4-oxazolyl-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-lactam），CAS注册编号 158792-27-9，化学分子式为 C50H49N15O15S，分子量 1132.08 g/mol。 N/A（分子式 C50H49N15O15S）的化学结构中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。在反相色谱体系中，

应用场景：针对化学分析用途，N/A（Alaninamide, L-threonyl-2- (1Z)-1-amino-1-propen-1-yl -4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6- 2-(1-aminoethenyl)-4-oxazolyl -5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-dideh

理化性质 Physical & Chemical Properties

中文名称N/A
分子式C50H49N15O15S
分子量1132.08 g/mol
外观形态淡黄色至黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）34.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2002年
含氮原子数15
含硫原子数1

相关专利 Related Patents

  1. 发明人张德明，周伟，冯建国. "一种N/A的合成方法" [P]. 中国发明专利, 专利号 CN 108309012 B, 授权公告日 2016-09-21.
  2. Williams B T, Anderson J P, Kumar R. "Method for the Synthesis of Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-lactam" [P]. US Patent, US 11697621 B2, 2021-01-04.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of N/A in Pharmaceutical Formulations". Chemosphere, 2020, 516, 9878-9897.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of N/A as an Impurity". Anal. Methods, 2016, 1520, 2170-2187.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-lactam Using HRMS and NMR". Phytochemistry, 2015, 1021, 3580-3588.

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