4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid CAS 1630763-90-4

4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid

纯度 97%+现货药物标准品
CAS 号1630763-90-4
分子式C21H20N2O6
分子量396.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid 4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid CAS 1630763-90-4 结构式 Chemical Structure

产品介绍 Description

CAS 1630763-90-4 对应的4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid（4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid）为 CATO 佳途药物标准品产品线成员。分子式 C21H20N2O6，分子量 396.39。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo2,1-aquinazolin-6-yl}butanoic acid的分子量为396.39 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo2,1-aquinazolin-6-yl}butanoic acid（4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo2,1-aquinazolin-6-yl}butanoic acid），CAS注册编号 1630763-90-4，化学分子式为 C21H20N2O6，分子量 396.39 g/mol。 依据分子式为 C21H20N2O6 的4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo2,1-aquinazolin-6-yl}butanoic acid结构特征，其分子内

应用场景：针对化学分析用途，4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo 2,1-a quinazolin-6-yl}butanoic acid（4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo 2,1-a quinazolin-6-yl}butanoic acid）是具有明确定量溯源的认证级对照品。 推荐以4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo 2,1-a quinazolin-6-yl}butanoic acid配制标

理化性质 Physical & Chemical Properties

中文名称4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid
分子式C21H20N2O6
分子量396.39 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）13.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1993年
含氮原子数2

相关专利 Related Patents

  1. Björnsson E, Mueller T C, Jørgensen K. "一种4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid的合成方法" [P]. European Patent, EP 3284990 A1, 2024-08-13.
  2. Anderson J P, Park J H, Kumar R. "Method for the Synthesis of 4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid" [P]. US Patent, US 10557416 B2, 2017-06-07.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2012, 1048, (11), 8107-8134.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid as an Impurity". Chromatographia, 2010, 2400, (8), 1318-1323.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 4-{9,10-dimethoxy-5,11-dioxo-5H,6H,6aH,11H-isoindolo[2,1-a]quinazolin-6-yl}butanoic acid Using HRMS and NMR". Biomed. Chromatogr., 2019, 617, 33-36.

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