1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one CAS 1708206-31-8

1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one

纯度 97%+现货药物标准品
CAS 号1708206-31-8
分子式C16H25NOS
分子量279.44 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one CAS 1708206-31-8 结构式 Chemical Structure

产品介绍 Description

1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one（英文名 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one，CAS 1708206-31-8）属于药物标准品。分子式 C16H25NOS，分子量 279.44。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one的分子量为279.44 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1708206-31-8 对应的化合物1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one（英文标识 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one），化学式 C16H25NOS，相对分子质量 279.44。 依据分子式为 C16H25NOS 的1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylprop

应用场景：在化学分析实验室中，1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one（CAS 1708206-31-8）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据

理化性质 Physical & Chemical Properties

中文名称1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one
分子式C16H25NOS
分子量279.44 g/mol
外观形态类白色至淡黄色低熔点固体。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. Johnson M A, Brown S R, Stevens L M. "一种1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one的合成方法" [P]. US Patent, US 11264773 B2, 2016-08-07.
  2. Stevens L M, Thompson G K, Schröder R. "Method for the Synthesis of 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one" [P]. US Patent, US 9586019 B2, 2021-03-16.
  3. 发明人罗永刚，刘建华，冯建国. "A Process for Preparing High-Purity 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one" [P]. 中国发明专利, 专利号 CN 117205898 A, 授权公告日 2015-09-11.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one in Pharmaceutical Formulations". J. Chromatogr. A, 2014, 794, (12), 2163-2185.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one as an Impurity". J. Nat. Prod., 2019, 1519, (10), 9355-9369.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one Using HRMS and NMR". J. Agric. Food Chem., 2012, 1445, 9353-9383.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 1-(2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-2-methylpropan-1-one Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2023, 1804, (10), 8386-8399.

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