CAS 1759-35-9

(3S,3aS,5aS,6R,9aS,9bS)-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid 1759-35-9 17|A-Hydroxy-5-oxo-A-nor-3,5-secoandrostan-3-oic Acid 3,5-Seco-A-norandrostan-17|A-ol-5-on-3-oic Acid 4-Nor-3,5-seco-5-oxo-17|A-hydroxyandrostan-3-oic Acid [3S-(3|A,3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid

纯度 97%+现货药物标准品
CAS 号1759-35-9
分子式C18H28O4
分子量308.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(3S,3aS,5aS,6R,9aS,9bS)-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid 1759-35-9 17|A-Hydroxy-5-oxo-A-nor-3,5-secoandrostan-3-oic Acid 3,5-Seco-A-norandrostan-17|A-ol-5-on-3-oic Acid 4-Nor-3,5-seco-5-oxo-17|A-hydroxyandrostan-3-oic Acid [3S-(3|A,3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid CAS 1759-35-9 结构式 Chemical Structure

产品介绍 Description

（英文名 (3S,3aS,5aS,6R,9aS,9bS)-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid 1759-35-9 17|A-Hydroxy-5-oxo-A-nor-3,5-secoandrostan-3-oic Acid 3,5-Seco-A-norandrostan-17|A-ol-5-on-3-oic Acid 4-Nor-3,5-seco-5-oxo-17|A-hydroxyandrostan-3-oic Acid [3S-(3|A,3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid，CAS 1759-35-9）属于药物标准品。分子式 C18H28O4，分子量 308.41。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

受分子结构中甾体骨架，含羟基，含醚键的影响，表现为类白色至淡黄色结晶性粉末。其固体形态的物理化学属性——包括308.41 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 化学式为 C18H28O4 的（(3S,3aS,5aS,6R,9aS,9bS)-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benzeindene-6-propanoic Acid 1759-35-9 17|A-Hydroxy-5-oxo-A-nor-3,5-secoandrostan-3-oic Acid 3,5-Seco-A-norandrostan-17|A-ol-5-on-3-oic Acid 4-Nor-3,5-seco-5-oxo-17|A-hydroxyandrostan-3-oic Acid 3S-(3|A,3a|A,5a|A,6|A,9a|A,9b|A)-Dodecahydro-3-hydroxy-3a,6

应用场景：在化学分析实验室中，（CAS 1759-35-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于室温保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C18H28O4
分子量308.41 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年

相关专利 Related Patents

  1. Rossi M, Jørgensen K, Lefèvre J P. "一种的合成方法" [P]. European Patent, EP 3707523 A1, 2015-09-05.
  2. 发明人钱学锋，林芳，高志强. "Method for the Synthesis of (3S,3aS,5aS,6R,9aS,9bS)-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid 1759-35-9 17|A-Hydroxy-5-oxo-A-nor-3,5-secoandrostan-3-oic Acid 3,5-Seco-A-norandrostan-17|A-ol-5-on-3-oic Acid 4-Nor-3,5-seco-5-oxo-17|A-hydroxyandrostan-3-oic Acid [3S-(3|A,3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid" [P]. 中国发明专利, 专利号 CN 110584289 A, 授权公告日 2016-02-02.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Methods, 2022, 1970, 9399-9406.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chem., 2017, 1940, 7665-7682.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of (3S,3aS,5aS,6R,9aS,9bS)-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid 1759-35-9 17|A-Hydroxy-5-oxo-A-nor-3,5-secoandrostan-3-oic Acid 3,5-Seco-A-norandrostan-17|A-ol-5-on-3-oic Acid 4-Nor-3,5-seco-5-oxo-17|A-hydroxyandrostan-3-oic Acid [3S-(3|A,3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid Using HRMS and NMR". Talanta, 2024, 1257, (3), 6884-6907.

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