4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride CAS 1779124-74-1

4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride

纯度 97%+现货药物标准品
CAS 号1779124-74-1
分子式C11H17N3O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride 4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride CAS 1779124-74-1 结构式 Chemical Structure

产品介绍 Description

CAS 1779124-74-1 对应的4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride（4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C11H17N3O2 HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride的分子量为259.73 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C11H17N3O2 HCl 的4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride（4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride），其CAS登记号是 1779124-74-1，分子量为 259.73 g/mol。 4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride（分子式 C11H17N3O2 HCl）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。由于结构

应用场景：针对化学分析用途，4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride（4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议：

理化性质 Physical & Chemical Properties

中文名称4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride
分子式C11H17N3O2 HCl
分子量259.73 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人胡光，林芳，马晓峰. "一种4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 112838003 A, 授权公告日 2016-01-05.
  2. Lefèvre J P, Björnsson E, Jørgensen K. "Method for the Synthesis of 4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride" [P]. European Patent, EP 3987440 A1, 2016-10-20.
  3. 发明人李文辉，周伟，钱学锋. "A Process for Preparing High-Purity 4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride" [P]. 中国发明专利, 专利号 CN 114133711 A, 授权公告日 2024-02-06.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride in Pharmaceutical Formulations". Molecules, 2016, 1751, 9212-9239.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride as an Impurity". Chemosphere, 2011, 567, (10), 4146-4170.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2019, 792, (1), 7943-7970.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 4-Methoxy-6-methyl-2-(piperidin-4-yloxy)pyrimidine hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2017, 1877, 571-582.

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