3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride CAS 1780940-10-4

3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号1780940-10-4
分子式C9H12N2O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride 3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride CAS 1780940-10-4 结构式 Chemical Structure

产品介绍 Description

CAS 1780940-10-4 对应的3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride（3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C9H12N2O2 HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在质量保证方面，3-methyl-5H,6H,7H,8H-imidazo1,5-apyridine-7-carboxylic acid hydrochloride的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 3-methyl-5H,6H,7H,8H-imidazo1,5-apyridine-7-carboxylic acid hydrochloride（3-methyl-5H,6H,7H,8H-imidazo1,5-apyridine-7-carboxylic acid hydrochloride），CAS注册编号 1780940-10-4，化学分子式为 C9H12N2O2 HCl，分子量 216.66 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代的影响，3-methyl-5H,6H,7H,8H-imidazo1,5-a

应用场景：3-methyl-5H,6H,7H,8H-imidazo 1,5-a pyridine-7-carboxylic acid hydrochloride（3-methyl-5H,6H,7H,8H-imidazo 1,5-a pyridine-7-carboxylic acid hydrochloride，CAS 1780940-10-4）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3-methyl-5H,6H,7H,8H-imidazo 1,5-a pyridine-7-carboxylic acid hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。

理化性质 Physical & Chemical Properties

中文名称3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride
分子式C9H12N2O2 HCl
分子量216.66 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人罗永刚，杨光，何建平. "一种3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 112316725 A, 授权公告日 2018-03-02.
  2. 发明人罗永刚，沈红梅，刘建华. "Method for the Synthesis of 3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride" [P]. 中国发明专利, 专利号 CN 109941495 A, 授权公告日 2025-04-24.
  3. 发明人沈红梅，赵玉洁，胡光. "A Process for Preparing High-Purity 3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride" [P]. 中国发明专利, 专利号 CN 115248343 B, 授权公告日 2021-12-08.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride in Pharmaceutical Formulations". Molecules, 2022, 985, (6), 9205-9231.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride as an Impurity". J. Sep. Sci., 2019, 1750, (9), 6732-6759.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride Using HRMS and NMR". J. Agric. Food Chem., 2019, 2178, 4984-5009.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 3-methyl-5H,6H,7H,8H-imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2020, 504, (1), 8625-8649.

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