methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate CAS 1797234-37-7

methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate

纯度 97%+现货药物标准品
CAS 号1797234-37-7
分子式C11H18N2O5
分子量258.27 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate CAS 1797234-37-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate（methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate，CAS 1797234-37-7），分子式 C11H18N2O5，分子量 258.27。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

CAS编号 1797234-37-7 对应的化合物methyl 5-({(tert-butoxy)carbonylamino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate（英文标识 methyl 5-({(tert-butoxy)carbonylamino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate），化学式 C11H18N2O5，相对分子质量 258.27。 依据分子式为 C11H18N2O5 的methyl 5-({(tert-butoxy)carbonylamino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate结构特征，其分子内含氨基酸衍生物，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 258.27 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 在定量分析

应用场景：从实际应用出发，methyl 5-({ (tert-butoxy)carbonyl amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate（CAS 1797234-37-7）在化学分析中作为关键的基准对照物质。 推荐以methyl 5-({ (tert-butoxy)carbonyl amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称

理化性质 Physical & Chemical Properties

中文名称methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate
分子式C11H18N2O5
分子量258.27 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
含氮原子数2

相关专利 Related Patents

  1. Mueller T C, Jørgensen K, Björnsson E. "一种methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate的合成方法" [P]. European Patent, EP 3279141 A1, 2018-08-21.
  2. Roberts E F, Hughes D C, Williams B T. "Method for the Synthesis of methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate" [P]. US Patent, US 9936785 B2, 2017-05-28.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate in Pharmaceutical Formulations". Food Chem., 2011, 630, (5), 7857-7864.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate as an Impurity". Chromatographia, 2010, 1021, (2), 5011-5034.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate Using HRMS and NMR". Chemosphere, 2023, 1546, (2), 6250-6267.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate Profile in Drug Substances According to ICH Guidelines". Talanta, 2015, 294, (2), 2295-2318.

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