7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride CAS 1797798-82-3

7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号1797798-82-3
分子式C10H17NO3 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride 7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride CAS 1797798-82-3 结构式 Chemical Structure

产品介绍 Description

7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride（7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride，CAS 号 1797798-82-3）是 CATO 佳途自主生产的药物标准品，分子式 C10H17NO3 HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 化学式为 C10H17NO3 HCl 的7-amino-8,8-dimethyl-2-oxabicyclo4.2.0octane-7-carboxylic acid hydrochloride（7-amino-8,8-dimethyl-2-oxabicyclo4.2.0octane-7-carboxylic acid hydrochloride），其CAS登记号是 1797798-82-3，分子量为 235.71 g/mol。 7-amino-8,8-dimethyl-2-oxabicyclo4.2.0octane-7-carboxylic acid hydrochloride（C10H17NO3 HCl）含有酰胺类，羧酸类，含羟基，含醚键，含氯取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，较高的碳氢比使其脂溶性较好，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于碳链较长，

应用场景：针对化学分析用途，7-amino-8,8-dimethyl-2-oxabicyclo 4.2.0 octane-7-carboxylic acid hydrochloride（7-amino-8,8-dimethyl-2-oxabicyclo 4.2.0 octane-7-carboxylic acid hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以7-amino-8,8-dimethyl-2-oxabicyclo 4.2.0 octane-7-carboxylic acid hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲

理化性质 Physical & Chemical Properties

中文名称7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride
分子式C10H17NO3 HCl
分子量235.71 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1994年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Brown S R, Lee S K, Hughes D C. "一种7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride的合成方法" [P]. US Patent, US 11656653 B2, 2025-02-21.
  2. Hughes D C, Williams B T, Brown S R. "Method for the Synthesis of 7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride" [P]. US Patent, US 10390125 B2, 2020-12-03.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride in Pharmaceutical Formulations". Anal. Methods, 2016, 475, (12), 1436-1464.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride as an Impurity". Anal. Chem., 2021, 1860, (12), 2500-2514.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2014, 1808, (7), 680-702.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 7-amino-8,8-dimethyl-2-oxabicyclo[4.2.0]octane-7-carboxylic acid hydrochloride Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2019, 1168, (8), 4999-5011.

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