1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride CAS 1803565-81-2

1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号1803565-81-2
分子式C11H17N3O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride CAS 1803565-81-2 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride（1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride，CAS 1803565-81-2），分子式 C11H17N3O2 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

1-(1-methyl-1H-pyrazol-4-yl)methylpiperidine-3-carboxylic acid hydrochloride的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 1-(1-methyl-1H-pyrazol-4-yl)methylpiperidine-3-carboxylic acid hydrochloride（1-(1-methyl-1H-pyrazol-4-yl)methylpiperidine-3-carboxylic acid hydrochloride），CAS注册编号 1803565-81-2，化学分子式为 C11H17N3O2 HCl，分子量 259.73 g/mol。 依据分子式为 C11H17N3O2 HCl 的1-(1-methyl-1H-pyrazol-4-yl)methylpiperidine-3-carboxylic acid hydrochloride结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，

应用场景：针对化学分析用途，1- (1-methyl-1H-pyrazol-4-yl)methyl piperidine-3-carboxylic acid hydrochloride（1- (1-methyl-1H-pyrazol-4-yl)methyl piperidine-3-carboxylic acid hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以1- (1-methyl-1H-pyrazol-4-yl)methyl piperidine-3-carboxylic acid hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲

理化性质 Physical & Chemical Properties

中文名称1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride
分子式C11H17N3O2 HCl
分子量259.73 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人马晓峰，郑宇鹏，张德明. "一种1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 115804551 A, 授权公告日 2025-03-19.
  2. 发明人韩伟，李文辉，朱建伟. "Method for the Synthesis of 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride" [P]. 中国发明专利, 专利号 CN 114497365 B, 授权公告日 2018-03-12.
  3. Rossi M, Sørensen M, Nowak P. "A Process for Preparing High-Purity 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride" [P]. European Patent, EP 3674135 A1, 2025-09-25.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride in Pharmaceutical Formulations". Food Chem., 2020, 2460, (1), 3392-3407.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride as an Impurity". Biomed. Chromatogr., 2022, 810, 5390-5396.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride Using HRMS and NMR". Chromatographia, 2019, 1580, 8110-8140.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid hydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2024, 204, (6), 6381-6399.

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