methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate CAS 1803565-83-4

methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate

纯度 97%+现货药物标准品
CAS 号1803565-83-4
分子式C14H22N2O4
分子量282.34 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate CAS 1803565-83-4 结构式 Chemical Structure

产品介绍 Description

CAS 1803565-83-4 对应的methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate（methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C14H22N2O4，分子量 282.34。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cycloheptad1,2oxazole-3-carboxylate的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C14H22N2O4 的methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cycloheptad1,2oxazole-3-carboxylate（methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cycloheptad1,2oxazole-3-carboxylate），其CAS登记号是 1803565-83-4，分子量为 282.34 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键的影响，methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cycloheptad1,2oxazole-3

应用场景：从实际应用出发，methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta d 1,2 oxazole-3-carboxylate（CAS 1803565-83-4）在化学分析中作为关键的基准对照物质。 推荐以methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta d 1,2 oxazole-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建

理化性质 Physical & Chemical Properties

中文名称methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate
分子式C14H22N2O4
分子量282.34 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
含氮原子数2

相关专利 Related Patents

  1. Nielsen H, Schröder R, Jørgensen K. "一种methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate的合成方法" [P]. European Patent, EP 3947810 A1, 2024-06-03.
  2. 发明人马晓峰，赵玉洁，唐晓军. "Method for the Synthesis of methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate" [P]. 中国发明专利, 专利号 CN 114464434 B, 授权公告日 2017-11-17.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate in Pharmaceutical Formulations". Anal. Methods, 2015, 484, 4980-5005.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate as an Impurity". Environ. Sci. Technol., 2014, 736, (9), 8103-8121.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate Using HRMS and NMR". Molecules, 2019, 491, 9201-9221.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate methyl 8a-(morpholin-4-yl)-3aH,4H,5H,6H,7H,8H,8aH-cyclohepta[d][1,2]oxazole-3-carboxylate Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2017, 646, 3142-3157.

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