benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate CAS 1803570-77-5
benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate
| CAS 号 | 1803570-77-5 |
| 分子式 | C19H20N2O4S |
| 分子量 | 372.44 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 1803570-77-5 对应的benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate（benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C19H20N2O4S，分子量 372.44。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate的产生途径与其化学式中黄酮骨架，酰胺类，含砜基，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate（benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate），CAS注册编号 1803570-77-5，化学分子式为 C19H20N2O4S，分子量 372.44 g/mol。 benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate（分子式 C19H20N2O4S）的化学结构中包含黄酮骨架，酰胺类，含砜基，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要
应用场景：benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate（benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate，CAS 1803570-77-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据
理化性质 Physical & Chemical Properties
| 中文名称 | benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate |
| 分子式 | C19H20N2O4S |
| 分子量 | 372.44 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末。（含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 11.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1995年 |
| 含氮原子数 | 2 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- 发明人刘建华，郑宇鹏，赵玉洁. "一种benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 110366988 B, 授权公告日 2015-12-26.
- 发明人陈志强，胡光，唐晓军. "Method for the Synthesis of benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 115145579 A, 授权公告日 2019-07-09.
参考文献 Literature
- Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate in Pharmaceutical Formulations". Phytochemistry, 2018, 461, 2860-2882.
- Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate as an Impurity". Chemosphere, 2017, 1891, 4870-4886.
- Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of benzyl 3-(2,3-dihydro-1H-indole-1-sulfonyl)azetidine-1-carboxylate Using HRMS and NMR". Sci. Total Environ., 2016, 133, (1), 3770-3795.
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