2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione CAS 1803583-25-6

2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione

纯度 97%+现货药物标准品
CAS 号1803583-25-6
分子式C15H15NO3S2
分子量321.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione 2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione CAS 1803583-25-6 结构式 Chemical Structure

产品介绍 Description

CAS 1803583-25-6 对应的2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione（2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione）为 CATO 佳途药物标准品产品线成员。分子式 C15H15NO3S2，分子量 321.41。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno2,3-c1$l^{6}thiopyran-6,6-dione（2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno2,3-c1$l^{6}thiopyran-6,6-dione），CAS注册编号 1803583-25-6，化学分子式为 C15H15NO3S2，分子量 321.41 g/mol。 2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno2,3-c1$l^{6}thiopyran-6,6-dione（分子式 C15H15NO3S2）的化学结构中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 推荐用于分析方法开发

应用场景：针对化学分析用途，2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno 2,3-c 1$l^{6} thiopyran-6,6-dione（2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno 2,3-c 1$l^{6} thiopyran-6,6-dione）是具有明确定量溯源的认证级对照品。 推荐以2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno 2,3-c 1$l^{6} thiopyran-6,6-dione配制标

理化性质 Physical & Chemical Properties

中文名称2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione
分子式C15H15NO3S2
分子量321.41 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
含氮原子数1
含硫原子数2

相关专利 Related Patents

  1. Björnsson E, Sørensen M, Lefèvre J P. "一种2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione的合成方法" [P]. European Patent, EP 3368661 A1, 2025-02-25.
  2. 发明人马晓峰，胡光，孙丽萍. "Method for the Synthesis of 2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione" [P]. 中国发明专利, 专利号 CN 108353117 B, 授权公告日 2018-05-05.
  3. Rossi M, Johansson L, Mueller T C. "A Process for Preparing High-Purity 2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione" [P]. European Patent, EP 3807006 A1, 2019-06-02.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione in Pharmaceutical Formulations". J. Chromatogr. A, 2020, 1068, 4631-4647.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione as an Impurity". Chemosphere, 2025, 1145, 7334-7356.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione Using HRMS and NMR". Environ. Sci. Technol., 2017, 370, 5474-5479.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate 2-amino-3-(4-methylbenzoyl)-4H,5H,7H-1,6$l^{6}-thieno[2,3-c][1$l^{6}]thiopyran-6,6-dione Profile in Drug Substances According to ICH Guidelines". Molecules, 2023, 117, (5), 5011-5015.

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