3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride CAS 1803587-80-5

3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride

纯度 97%+现货药物标准品
CAS 号1803587-80-5
分子式C10H12N4S HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride 3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride CAS 1803587-80-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride（3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride，CAS 1803587-80-5），分子式 C10H12N4S HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C10H12N4S HCl 的3-hydrazinyl-8-thia-4,6-diazatricyclo7.4.0.0^{2,7}trideca-1(9),2,4,6-tetraene hydrochloride（3-hydrazinyl-8-thia-4,6-diazatricyclo7.4.0.0^{2,7}trideca-1(9),2,4,6-tetraene hydrochloride），其CAS登记号是 1803587-80-5，分子量为 256.75 g/mol。 受分子结构中含氮杂环结构，含氰基，含硫有机，含氯取代的影响，3-hydrazinyl-8-thia-4,6-diazatricyclo7.4.0.0^{2,7}trideca-1(9),2,4,6-tetraene hydrochloride表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特

应用场景：针对化学分析用途，3-hydrazinyl-8-thia-4,6-diazatricyclo 7.4.0.0^{2,7} trideca-1(9),2,4,6-tetraene hydrochloride（3-hydrazinyl-8-thia-4,6-diazatricyclo 7.4.0.0^{2,7} trideca-1(9),2,4,6-tetraene hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以3-hydrazinyl-8-thia-4,6-diazatricyclo 7.4.0.0^{2,7} trideca-1(9),2,4,6-tetraene h

理化性质 Physical & Chemical Properties

中文名称3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride
分子式C10H12N4S HCl
分子量256.75 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人刘建华，陈志强，黄志刚. "一种3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 111104587 B, 授权公告日 2020-05-18.
  2. O'Brien P Q, Thompson G K, Williams B T. "Method for the Synthesis of 3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride" [P]. US Patent, US 10602715 B2, 2021-06-13.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride in Pharmaceutical Formulations". Talanta, 2011, 643, (6), 948-956.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride as an Impurity". Food Chem., 2012, 723, 5685-5712.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride Using HRMS and NMR". Biomed. Chromatogr., 2020, 588, 7758-7769.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate 3-hydrazinyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene hydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2010, 1786, 6354-6363.

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