tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate CAS 1803593-10-3

tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate

纯度 97%+现货药物标准品
CAS 号1803593-10-3
分子式C17H22N2O4
分子量318.37 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate CAS 1803593-10-3 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate（tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate，CAS 1803593-10-3），分子式 C17H22N2O4，分子量 318.37。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

受分子结构中黄酮骨架，酰胺类，含羟基，含醚键的影响，tert-butyl N-{3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-ylmethyl}carbamate表现为淡黄色至黄色结晶性粉末。其固体形态的物理化学属性——包括318.37 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 CAS编号 1803593-10-3 对应的化合物tert-butyl N-{3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-ylmethyl}carbamate（英文标识 tert-butyl N-{3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-ylmethyl}carbamate），化学式 C17H22N2O4，相对分子质量 318.37。 推荐用于分

应用场景：tert-butyl N-{ 3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl methyl}carbamate（tert-butyl N-{ 3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl methyl}carbamate，CAS 1803593-10-3）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以tert-butyl N-{ 3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-o

理化性质 Physical & Chemical Properties

中文名称tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate
分子式C17H22N2O4
分子量318.37 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
含氮原子数2

相关专利 Related Patents

  1. Yamamoto T, Brown S R, Johnson M A. "一种tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate的合成方法" [P]. US Patent, US 9387578 B2, 2015-01-01.
  2. 发明人陈志强，黄志刚，孙丽萍. "Method for the Synthesis of tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate" [P]. 中国发明专利, 专利号 CN 113870412 A, 授权公告日 2015-01-12.
  3. 发明人徐明华，周伟，陈志强. "A Process for Preparing High-Purity tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate" [P]. 中国发明专利, 专利号 CN 110618277 B, 授权公告日 2020-09-21.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate in Pharmaceutical Formulations". Chromatographia, 2016, 1259, (9), 2234-2253.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate as an Impurity". Talanta, 2011, 1241, (5), 6604-6623.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate Using HRMS and NMR". Anal. Chem., 2018, 825, 2170-2191.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate tert-butyl N-{[3-(2,3-dihydro-1-benzofuran-6-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}carbamate Profile in Drug Substances According to ICH Guidelines". Molecules, 2018, 2377, 3657-3663.

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