7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride CAS 1803603-84-0

7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride

纯度 97%+现货药物标准品
CAS 号1803603-84-0
分子式C21H22F3N3O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride 7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride CAS 1803603-84-0 结构式 Chemical Structure

产品介绍 Description

7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride（英文名 7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride，CAS 1803603-84-0）属于药物标准品。分子式 C21H22F3N3O HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括7-benzyl-2-4-(trifluoromethyl)phenyl-3H,4H,5H,6H,7H,8H-pyrido3,4-dpyrimidin-4-one hydrochloride在内的目标物的控制。 化学式为 C21H22F3N3O HCl 的7-benzyl-2-4-(trifluoromethyl)phenyl-3H,4H,5H,6H,7H,8H-pyrido3,4-dpyrimidin-4-one hydrochloride（7-benzyl-2-4-(trifluoromethyl)phenyl-3H,4H,5H,6H,7H,8H-pyrido3,4-dpyrimidin-4-one hydrochloride），其CAS登记号是 1803603-84-0，分子量为 425.88 g/mol。 7-benzyl-2-4-(trifluoromethyl)phenyl-3H,4H,5H,6H,7H,8H-pyrido3,4-dpyrimidin-4-one hydrochl

应用场景：7-benzyl-2- 4-(trifluoromethyl)phenyl -3H,4H,5H,6H,7H,8H-pyrido 3,4-d pyrimidin-4-one hydrochloride（7-benzyl-2- 4-(trifluoromethyl)phenyl -3H,4H,5H,6H,7H,8H-pyrido 3,4-d pyrimidin-4-one hydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以7-benzyl-2- 4-(trifluoromethyl)phenyl -3H,4H,5H,6H,7H,8H-pyrido 3,4-d

理化性质 Physical & Chemical Properties

中文名称7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride
分子式C21H22F3N3O HCl
分子量425.88 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F/Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人张德明，孙丽萍，徐明华. "一种7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 111056134 A, 授权公告日 2024-03-09.
  2. 发明人黄志刚，沈红梅，陈志强. "Method for the Synthesis of 7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride" [P]. 中国发明专利, 专利号 CN 114464103 B, 授权公告日 2018-02-21.
  3. Lee S K, O'Brien P Q, Williams B T. "A Process for Preparing High-Purity 7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride" [P]. US Patent, US 9268529 B2, 2015-11-25.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2011, 588, (3), 1094-1121.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride as an Impurity". Food Chem., 2025, 1702, 3480-3496.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride Using HRMS and NMR". Sci. Total Environ., 2017, 2291, (5), 1478-1508.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate 7-benzyl-2-[4-(trifluoromethyl)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2012, 1300, (8), 8795-8814.

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