5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride CAS 1803605-06-2

5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride

纯度 97%+现货药物标准品
CAS 号1803605-06-2
分子式C12H20N4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride 5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride CAS 1803605-06-2 结构式 Chemical Structure

产品介绍 Description

CAS 1803605-06-2 对应的5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride（5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C12H20N4O 2*HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo1,5-apyridine-3-carboxamide dihydrochloride在内的目标物的控制。 化学式为 C12H20N4O 2HCl 的5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo1,5-apyridine-3-carboxamide dihydrochloride（5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo1,5-apyridine-3-carboxamide dihydrochloride），其CAS登记号是 1803605-06-2，分子量为 272.78 g/mol。 依据分子式为 C12H20N4O 2HCl 的5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo1,5-apyridine-3-carbox

应用场景：5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo 1,5-a pyridine-3-carboxamide dihydrochloride（5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo 1,5-a pyridine-3-carboxamide dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo 1,5-a pyridine-3-car

理化性质 Physical & Chemical Properties

中文名称5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride
分子式C12H20N4O 2*HCl
分子量272.78 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. Schröder R, Johnson M A, Brown S R. "一种5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride的合成方法" [P]. US Patent, US 10644412 B2, 2017-12-24.
  2. 发明人张德明，王建平，郭海燕. "Method for the Synthesis of 5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride" [P]. 中国发明专利, 专利号 CN 113047266 B, 授权公告日 2022-02-16.
  3. Davis P L, Park J H, Chen K W. "A Process for Preparing High-Purity 5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride" [P]. US Patent, US 10726127 B2, 2018-04-28.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2023, 435, (12), 3175-3199.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride as an Impurity". Rapid Commun. Mass Spectrom., 2014, 1247, 412-419.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride Using HRMS and NMR". J. Agric. Food Chem., 2014, 1559, (6), 5760-5781.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate 5-(aminomethyl)-N-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxamide dihydrochloride Profile in Drug Substances According to ICH Guidelines". Food Chem., 2019, 558, (11), 660-687.

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