2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride CAS 1803605-20-0

2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1803605-20-0
分子式C10H16N4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride CAS 1803605-20-0 结构式 Chemical Structure

产品介绍 Description

2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride（2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride，CAS 号 1803605-20-0）是 CATO 佳途自主生产的药物标准品，分子式 C10H16N4O 2*HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride在内的目标物的控制。 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride（2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride），CAS注册编号 1803605-20-0，化学分子式为 C10H16N4O 2HCl，分子量 244.72 g/mol。 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride（C10H16N4O 2HCl）含有含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代。卤素取代增加了化合物的密度和沸点，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中的氮原子赋予

应用场景：2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride（2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储

理化性质 Physical & Chemical Properties

中文名称2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride
分子式C10H16N4O 2*HCl
分子量244.72 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人冯建国，刘建华，黄志刚. "一种2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 117993486 A, 授权公告日 2025-08-24.
  2. Schröder R, Mueller T, Davis P L. "Method for the Synthesis of 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride" [P]. US Patent, US 10801923 B2, 2021-02-09.
  3. 发明人黄志刚，钱学锋，罗永刚. "A Process for Preparing High-Purity 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride" [P]. 中国发明专利, 专利号 CN 112754840 A, 授权公告日 2024-05-19.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride in Pharmaceutical Formulations". Environ. Sci. Technol., 2020, 1393, 3572-3581.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride as an Impurity". Phytochemistry, 2013, 708, 4394-4416.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride Using HRMS and NMR". Chemosphere, 2011, 1834, 6587-6595.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methylpiperazine dihydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2012, 167, (4), 6609-6618.

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