2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde CAS 1803608-22-1
2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde
| CAS 号 | 1803608-22-1 |
| 分子式 | C12H21NO2SSi |
| 分子量 | 271.45 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde（英文名 2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde，CAS 1803608-22-1）属于药物标准品。分子式 C12H21NO2SSi，分子量 271.45。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C12H21NO2SSi 的2-{1-(tert-butyldimethylsilyl)oxyethyl}-1,3-thiazole-5-carbaldehyde（2-{1-(tert-butyldimethylsilyl)oxyethyl}-1,3-thiazole-5-carbaldehyde），其CAS登记号是 1803608-22-1，分子量为 271.45 g/mol。 依据分子式为 C12H21NO2SSi 的2-{1-(tert-butyldimethylsilyl)oxyethyl}-1,3-thiazole-5-carbaldehyde结构特征，其分子内含酰胺类，含砜基，羧酸类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈
应用场景：从实际应用出发，2-{1- (tert-butyldimethylsilyl)oxy ethyl}-1,3-thiazole-5-carbaldehyde（CAS 1803608-22-1）在化学分析中作为关键的基准对照物质。 推荐以2-{1- (tert-butyldimethylsilyl)oxy ethyl}-1,3-thiazole-5-carbaldehyde配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议
理化性质 Physical & Chemical Properties
| 中文名称 | 2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde |
| 分子式 | C12H21NO2SSi |
| 分子量 | 271.45 g/mol |
| 外观形态 | 白色至淡黄色结晶性粉末。（含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 3.0 |
| UV特征 | 有紫外吸收 |
| CAS登记年份（估） | 1995年 |
| 含氮原子数 | 1 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- 发明人杨光，赵玉洁，郭海燕. "一种2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde的合成方法" [P]. 中国发明专利, 专利号 CN 109521320 A, 授权公告日 2016-04-19.
- 发明人赵玉洁，朱建伟，高志强. "Method for the Synthesis of 2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde" [P]. 中国发明专利, 专利号 CN 110772847 A, 授权公告日 2024-09-20.
参考文献 Literature
- Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde in Pharmaceutical Formulations". Biomed. Chromatogr., 2015, 1678, (7), 8472-8501.
- Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde as an Impurity". Food Chem., 2018, 1597, (4), 4132-4137.
- Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2010, 2182, (12), 180-205.
- Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde Profile in Drug Substances According to ICH Guidelines". Molecules, 2015, 2154, (5), 2495-2510.
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