N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide CAS 1803609-46-2

N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide

纯度 97%+现货药物标准品
CAS 号1803609-46-2
分子式C12H12F3NO2
分子量259.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide CAS 1803609-46-2 结构式 Chemical Structure

产品介绍 Description

N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide（N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide）是药物分析与质量控制领域常用的药物标准品，CAS 号 1803609-46-2。分子式 C12H12F3NO2，分子量 259.22。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide在内的目标物的控制。 化学式为 C12H12F3NO2 的N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide（N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide），其CAS登记号是 1803609-46-2，分子量为 259.22 g/mol。 N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide（分子式 C12H12F3NO2）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。由

应用场景：N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide（N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide，CAS 1803609-46-2）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）

理化性质 Physical & Chemical Properties

中文名称N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide
分子式C12H12F3NO2
分子量259.22 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. 发明人孙丽萍，陈志强，何建平. "一种N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide的合成方法" [P]. 中国发明专利, 专利号 CN 114986476 A, 授权公告日 2020-03-23.
  2. 发明人林芳，沈红梅，何建平. "Method for the Synthesis of N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide" [P]. 中国发明专利, 专利号 CN 114317536 A, 授权公告日 2025-07-25.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide in Pharmaceutical Formulations". Molecules, 2017, 362, (3), 6851-6863.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide as an Impurity". J. Agric. Food Chem., 2022, 87, 2769-2786.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide Using HRMS and NMR". J. Nat. Prod., 2022, 2468, 5600-5609.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate N-methoxy-N-methyl-2-(3,4,5-trifluorophenyl)cyclopropane-1-carboxamide Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2024, 978, (5), 8197-8225.

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