3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride CAS 1803610-10-7

3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

纯度 97%+现货药物标准品
CAS 号1803610-10-7
分子式C10H12N4S HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride CAS 1803610-10-7 结构式 Chemical Structure

产品介绍 Description

3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride（英文名 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride，CAS 1803610-10-7）属于药物标准品。分子式 C10H12N4S HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine hydrochloride的分子量为256.75 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1803610-10-7 对应的化合物3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine hydrochloride（英文标识 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine hydrochloride），化学式 C10H12N4S HCl，相对分子质量 256.75。 依据分子式为 C10H12N4S HCl 的3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine hydrochloride结构特征，其分子内含含氮杂环结构，含氰基，含硫有机，含氯取代，这

应用场景：3-(thiophen-3-ylmethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazine hydrochloride（3-(thiophen-3-ylmethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazine hydrochloride，CAS 1803610-10-7）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3-(thiophen-3-ylmethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazine hydrochloride配制标准系列工作溶液，用

理化性质 Physical & Chemical Properties

中文名称3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
分子式C10H12N4S HCl
分子量256.75 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人唐晓军，韩伟，朱建伟. "一种3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 115755964 B, 授权公告日 2019-03-22.
  2. 发明人冯建国，李文辉，林芳. "Method for the Synthesis of 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride" [P]. 中国发明专利, 专利号 CN 110680448 A, 授权公告日 2018-09-26.
  3. Roberts E F, Fischer A B, Hughes D C. "A Process for Preparing High-Purity 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride" [P]. US Patent, US 11177917 B2, 2022-01-17.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride in Pharmaceutical Formulations". Anal. Chem., 2019, 1012, 9166-9196.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride as an Impurity". J. Sep. Sci., 2023, 1610, (4), 7848-7875.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Using HRMS and NMR". J. Nat. Prod., 2019, 1179, 7761-7773.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 3-(thiophen-3-ylmethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2024, 987, (1), 2656-2660.

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