3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride CAS 1807939-02-1

3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride

纯度 97%+现货药物标准品
CAS 号1807939-02-1
分子式C10H15N3O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride 3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride CAS 1807939-02-1 结构式 Chemical Structure

产品介绍 Description

3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride（3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1807939-02-1。分子式 C10H15N3O2 HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

化学式为 C10H15N3O2 HCl 的3-cyclopropyl-5-(2R,4S)-4-methoxypyrrolidin-2-yl-1,2,4-oxadiazole hydrochloride（3-cyclopropyl-5-(2R,4S)-4-methoxypyrrolidin-2-yl-1,2,4-oxadiazole hydrochloride），其CAS登记号是 1807939-02-1，分子量为 245.71 g/mol。 依据分子式为 C10H15N3O2 HCl 的3-cyclopropyl-5-(2R,4S)-4-methoxypyrrolidin-2-yl-1,2,4-oxadiazole hydrochloride结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 245.71 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 在定量分析中

应用场景：针对化学分析用途，3-cyclopropyl-5- (2R,4S)-4-methoxypyrrolidin-2-yl -1,2,4-oxadiazole hydrochloride（3-cyclopropyl-5- (2R,4S)-4-methoxypyrrolidin-2-yl -1,2,4-oxadiazole hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以3-cyclopropyl-5- (2R,4S)-4-methoxypyrrolidin-2-yl -1,2,4-oxadiazole hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法

理化性质 Physical & Chemical Properties

中文名称3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride
分子式C10H15N3O2 HCl
分子量245.71 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人孙丽萍，黄志刚，李文辉. "一种3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 116279673 B, 授权公告日 2023-05-03.
  2. Klinger H, Mueller T, Park J H. "Method for the Synthesis of 3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride" [P]. US Patent, US 10067851 B2, 2015-06-27.
  3. Williams B T, Davis P L, Roberts E F. "A Process for Preparing High-Purity 3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride" [P]. US Patent, US 11136681 B2, 2025-04-19.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride in Pharmaceutical Formulations". Molecules, 2023, 2333, (6), 9026-9033.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride as an Impurity". Environ. Sci. Technol., 2021, 744, (7), 3820-3843.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride Using HRMS and NMR". J. Chromatogr. A, 2023, 1720, (8), 6093-6107.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate 3-cyclopropyl-5-[(2R,4S)-4-methoxypyrrolidin-2-yl]-1,2,4-oxadiazole hydrochloride Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2021, 715, (10), 5419-5422.

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