{[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride CAS 1807939-09-8

{[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1807939-09-8
分子式C9H15FN4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

{[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride {[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride CAS 1807939-09-8 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的{[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride（{[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride）为药物标准品，CAS 登记号 1807939-09-8，分子式 C9H15FN4O 2*HCl。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

受分子结构中酰胺类，含羟基，含醚键，含氟/氯取代的影响，{cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-ylmethyl}(methyl)amine dihydrochloride表现为白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）。其固体形态的物理化学属性——包括250.70 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。由于结构中存在共轭发色团，该化合物在200-400 nm区间具有显著的紫外吸收，便于HPLC-UV检测。 化学式为 C9H15FN4O 2HCl 的{cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-ylmethyl}(methyl)amine dihydrochloride（{cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-ylmethyl}(methyl)amine dihy

应用场景：{ cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl methyl}(methyl)amine dihydrochloride（{ cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl methyl}(methyl)amine dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以{ cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl met

理化性质 Physical & Chemical Properties

中文名称{[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride
分子式C9H15FN4O 2*HCl
分子量250.70 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1995年
卤素含量F/Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人罗永刚，杨光，何建平. "一种{[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 116974133 B, 授权公告日 2018-01-21.
  2. 发明人赵玉洁，唐晓军，冯建国. "Method for the Synthesis of {[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride" [P]. 中国发明专利, 专利号 CN 115479811 B, 授权公告日 2018-04-07.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of {[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride in Pharmaceutical Formulations". J. Agric. Food Chem., 2020, 911, (6), 8041-8069.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of {[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride as an Impurity". Molecules, 2014, 162, (1), 1526-1550.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of {[cis-4-fluoro-1-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride Using HRMS and NMR". Sci. Total Environ., 2021, 1115, 9076-9091.

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