{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride CAS 1807941-78-1

{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1807941-78-1
分子式C10H17FN4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride {[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride CAS 1807941-78-1 结构式 Chemical Structure

产品介绍 Description

{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride（英文名 {[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride，CAS 1807941-78-1）属于药物标准品。分子式 C10H17FN4O 2*HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

CAS编号 1807941-78-1 对应的化合物{(2S,4S)-4-fluoro-1-(5-methyl-1,2,4-oxadiazol-3-yl)methylpyrrolidin-2-ylmethyl}(methyl)amine dihydrochloride（英文标识 {(2S,4S)-4-fluoro-1-(5-methyl-1,2,4-oxadiazol-3-yl)methylpyrrolidin-2-ylmethyl}(methyl)amine dihydrochloride），化学式 C10H17FN4O 2HCl，相对分子质量 264.73。 依据分子式为 C10H17FN4O 2HCl 的{(2S,4S)-4-fluoro-1-(5-methyl-1,2,4-oxadiazol-3-yl)methylpyrrolidin-2-ylmethyl}(methyl)amine dihydrochloride结构特征，其分子内含酰胺类，含羟基，含醚键，含氟/氯取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 264.73 g/mo

应用场景：在化学分析实验室中，{ (2S,4S)-4-fluoro-1- (5-methyl-1,2,4-oxadiazol-3-yl)methyl pyrrolidin-2-yl methyl}(methyl)amine dihydrochloride（CAS 1807941-78-1）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以{ (2S,4S)-4-fluoro-1- (5-methyl-1,2,4-oxadiazol-3-yl)methyl pyrrolidin-2-yl methyl}(methyl)amine dihydrochloride配制标准系列工作溶液，用于建

理化性质 Physical & Chemical Properties

中文名称{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride
分子式C10H17FN4O 2*HCl
分子量264.73 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1995年
卤素含量F/Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人钱学锋，刘建华，李文辉. "一种{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 112609987 B, 授权公告日 2024-02-28.
  2. 发明人马晓峰，徐明华，张德明. "Method for the Synthesis of {[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride" [P]. 中国发明专利, 专利号 CN 108959845 A, 授权公告日 2024-12-06.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of {[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride in Pharmaceutical Formulations". Food Chem., 2016, 1592, (5), 3861-3890.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of {[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride as an Impurity". Molecules, 2017, 1888, 4042-4060.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of {[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride Using HRMS and NMR". J. Pharm. Biomed. Anal., 2019, 1260, (10), 5435-5461.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate {[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine dihydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2020, 1176, (4), 6701-6723.

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