[cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride CAS 1820583-09-2

[cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1820583-09-2
分子式C10H16FN3O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride [cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride CAS 1820583-09-2 结构式 Chemical Structure

产品介绍 Description

[cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride（英文名 [cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride，CAS 1820583-09-2）属于药物标准品。分子式 C10H16FN3O 2*HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

cis-4-fluoro-1-(5-methyl-1,2-oxazol-4-yl)methylpyrrolidin-2-ylmethanamine dihydrochloride的产生途径与其化学式中酰胺类，含羟基，含醚键，含氟/氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1820583-09-2 对应的化合物cis-4-fluoro-1-(5-methyl-1,2-oxazol-4-yl)methylpyrrolidin-2-ylmethanamine dihydrochloride（英文标识 cis-4-fluoro-1-(5-methyl-1,2-oxazol-4-yl)methylpyrrolidin-2-ylmethanamine dihydrochloride），化学式 C10H16FN3O 2HCl，相对分子质量 249.71。 从化学结构特征来看，cis-4-fluoro-1-(5-methyl-1,2-oxazol-4-yl)methylpyrrolidin-2-ylmethanami

应用场景： cis-4-fluoro-1- (5-methyl-1,2-oxazol-4-yl)methyl pyrrolidin-2-yl methanamine dihydrochloride（ cis-4-fluoro-1- (5-methyl-1,2-oxazol-4-yl)methyl pyrrolidin-2-yl methanamine dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以 cis-4-fluoro-1- (5-methyl-1,2-oxazol-4-yl)methyl pyrrolidin-2-yl methanamine dih

理化性质 Physical & Chemical Properties

中文名称[cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride
分子式C10H16FN3O 2*HCl
分子量249.71 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1995年
卤素含量F/Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人徐明华，王建平，张德明. "一种[cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 117944191 B, 授权公告日 2019-10-24.
  2. 发明人杨光，陈志强，周伟. "Method for the Synthesis of [cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride" [P]. 中国发明专利, 专利号 CN 112458768 A, 授权公告日 2019-06-15.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of [cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2021, 211, (4), 7015-7033.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of [cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride as an Impurity". Sci. Total Environ., 2013, 2059, 9440-9466.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of [cis-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride Using HRMS and NMR". J. Chromatogr. A, 2019, 490, 2011-2029.

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