(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate CAS 185556-78-9

(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate

纯度 97%+现货药物标准品
CAS 号185556-78-9
分子式C25H42N2O8Si2
分子量554.78 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate (Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate CAS 185556-78-9 结构式 Chemical Structure

产品介绍 Description

(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate（英文名 (Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate，CAS 185556-78-9）属于药物标准品。分子式 C25H42N2O8Si2，分子量 554.78。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 化学式为 C25H42N2O8Si2 的(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo3,2-f1,3,5,2,4trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate（(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo3,2-f1,3,5,2,4trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate），其CAS登记号是 185556-78-9，分子量为 554.78 g/mol。 依据分子式为 C25H42N2O8Si2 的(Z)-ethyl 2-((6a

应用场景：在化学分析实验室中，(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo 3,2-f 1,3,5,2,4 trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate（CAS 185556-78-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,

理化性质 Physical & Chemical Properties

中文名称(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate
分子式C25H42N2O8Si2
分子量554.78 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2010年
含氮原子数2

相关专利 Related Patents

  1. 发明人钱学锋，王建平，郭海燕. "一种(Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate的合成方法" [P]. 中国发明专利, 专利号 CN 108621645 B, 授权公告日 2024-10-09.
  2. Patel M V, Brown S R, Davis P L. "Method for the Synthesis of (Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate" [P]. US Patent, US 11102986 B2, 2022-07-22.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of (Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate in Pharmaceutical Formulations". J. Agric. Food Chem., 2010, 1872, (8), 9346-9353.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of (Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate as an Impurity". Chemosphere, 2016, 2157, (9), 9117-9139.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of (Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate Using HRMS and NMR". J. Sep. Sci., 2015, 1870, (11), 8228-8251.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate (Z)-ethyl 2-((6aR,8R,9aS)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyl-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9(6aH,8H,9aH)-ylidene)acetate Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2023, 821, (9), 298-308.

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