3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸 CAS 1856-98-0
3,18-Diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid
| CAS 号 | 1856-98-0 |
| 分子式 | C33H42N4O6 |
| 分子量 | 590.71 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸（3,18-Diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 1856-98-0。分子式 C33H42N4O6，分子量 590.71。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸（3,18-Diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid），CAS注册编号 1856-98-0，化学分子式为 C33H42N4O6，分子量 590.71 g/mol。 3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸（C33H42N4O6）含有含氮杂环结构，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD,
应用场景：针对化学分析用途，3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸（3,18-Diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid）是具有明确定量溯源的认证级对照品。 推荐以3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸配制标准
理化性质 Physical & Chemical Properties
| 中文名称 | 3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸 |
| 分子式 | C33H42N4O6 |
| 分子量 | 590.71 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 15.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1957年 |
| 含氮原子数 | 4 |
相关专利 Related Patents
- 发明人马晓峰，钱学锋，赵玉洁. "一种3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸的合成方法" [P]. 中国发明专利, 专利号 CN 110717632 B, 授权公告日 2016-02-12.
- 发明人郑宇鹏，沈红梅，罗永刚. "Method for the Synthesis of 3,18-Diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" [P]. 中国发明专利, 专利号 CN 114733111 A, 授权公告日 2018-09-03.
- 发明人冯建国，林芳，赵玉洁. "A Process for Preparing High-Purity 3,18-Diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" [P]. 中国发明专利, 专利号 CN 109966095 B, 授权公告日 2025-12-14.
参考文献 Literature
- Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸 in Pharmaceutical Formulations". Anal. Chem., 2018, 2173, 4858-4883.
- Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3,18-二乙基-1,4,5,15,16,19,22,24-八氢-2,7,13,17-四甲基-1,19-dioxo-21H-biline-8,12-二丙酸 as an Impurity". Sci. Total Environ., 2015, 970, 4359-4369.
- Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 3,18-Diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2016, 1044, (5), 5492-5501.
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