3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid CAS 1864058-45-6

3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid

纯度 97%+现货药物标准品
CAS 号1864058-45-6
分子式C10H12N4O2 C2HF3O2
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid 3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid CAS 1864058-45-6 结构式 Chemical Structure

产品介绍 Description

3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid（英文名 3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid，CAS 1864058-45-6）属于药物标准品。分子式 C10H12N4O2 C2HF3O2。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，3-({7-methyl-1,2,4triazolo1,5-apyridin-5-yl}amino)propanoic acid, trifluoroacetic acid的分子量为334.25 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 3-({7-methyl-1,2,4triazolo1,5-apyridin-5-yl}amino)propanoic acid, trifluoroacetic acid（3-({7-methyl-1,2,4triazolo1,5-apyridin-5-yl}amino)propanoic acid, trifluoroacetic acid），CAS注册编号 1864058-45-6，化学分子式为 C10H12N4O2 C2HF3O2，分子量 334.25 g/mol。 从化学结构特征来看，3-({7-methyl-1,2,4triazolo1,5-apyridin-5-yl}amino)propanoic acid, trifluoroacetic acid的分

应用场景：针对化学分析用途，3-({7-methyl- 1,2,4 triazolo 1,5-a pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid（3-({7-methyl- 1,2,4 triazolo 1,5-a pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid）是具有明确定量溯源的认证级对照品。 推荐以3-({7-methyl- 1,2,4 triazolo 1,5-a pyridin-5-yl}amino)propanoic acid, trifluoroacetic a

理化性质 Physical & Chemical Properties

中文名称3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid
分子式C10H12N4O2 C2HF3O2
分子量334.25 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F取代
含氮原子数4

相关专利 Related Patents

  1. 发明人赵玉洁，李文辉，杨光. "一种3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid的合成方法" [P]. 中国发明专利, 专利号 CN 109972757 A, 授权公告日 2022-08-16.
  2. Martínez F, Mueller T C, Lefèvre J P. "Method for the Synthesis of 3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid" [P]. European Patent, EP 3240365 A1, 2025-04-01.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid in Pharmaceutical Formulations". Anal. Methods, 2018, 1017, 5399-5414.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid as an Impurity". J. Agric. Food Chem., 2023, 905, 6791-6815.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid Using HRMS and NMR". Talanta, 2022, 124, 9037-9053.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate 3-({7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}amino)propanoic acid, trifluoroacetic acid Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2020, 1032, 6712-6730.

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