rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid CAS 1909293-78-2

rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1909293-78-2
分子式C11H15N3O3
分子量237.26 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid CAS 1909293-78-2 结构式 Chemical Structure

产品介绍 Description

rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid（rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid，CAS 号 1909293-78-2）是 CATO 佳途自主生产的药物标准品，分子式 C11H15N3O3，分子量 237.26。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

作为认证标准物质（CRM），rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 CAS编号 1909293-78-2 对应的化合物rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid（英文标识 rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid），化学式 C11H15N3O3，相对分子质量 237.26。 依据分子式为 C11H15N3O3 的rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxo

应用场景：针对化学分析用途，rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid（rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid
分子式C11H15N3O3
分子量237.26 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
含氮原子数3

相关专利 Related Patents

  1. 发明人陈志强，张德明，王建平. "一种rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 115418208 A, 授权公告日 2016-02-05.
  2. Kowalski A, Mueller T C, Martínez F. "Method for the Synthesis of rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid" [P]. European Patent, EP 3820589 A1, 2016-07-11.
  3. 发明人杨光，沈红梅，唐晓军. "A Process for Preparing High-Purity rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 113444613 A, 授权公告日 2019-08-19.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid in Pharmaceutical Formulations". Anal. Chem., 2010, 1512, (1), 818-847.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid as an Impurity". J. Nat. Prod., 2020, 1305, 9466-9493.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid Using HRMS and NMR". J. Sep. Sci., 2017, 1745, (5), 3479-3488.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2014, 1692, 1256-1280.

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