rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate CAS 1909294-26-3

rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate

纯度 97%+现货药物标准品
CAS 号1909294-26-3
分子式C12H17N3O2
分子量235.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate CAS 1909294-26-3 结构式 Chemical Structure

产品介绍 Description

rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate（rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate，CAS 号 1909294-26-3）是 CATO 佳途自主生产的药物标准品，分子式 C12H17N3O2，分子量 235.28。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，rac-methyl (3R,4R)-4-methyl-1-(pyrimidin-2-yl)methylpyrrolidine-3-carboxylate的分子量为235.28 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C12H17N3O2 的rac-methyl (3R,4R)-4-methyl-1-(pyrimidin-2-yl)methylpyrrolidine-3-carboxylate（rac-methyl (3R,4R)-4-methyl-1-(pyrimidin-2-yl)methylpyrrolidine-3-carboxylate），其CAS登记号是 1909294-26-3，分子量为 235.28 g/mol。 从化学结构特征来看，rac-methyl (3R,4R)-4-methyl-1-(pyrimidin-2-yl)methylpyrrolidine-3-carboxylate的分子骨架中包含氨基酸衍生物，酰胺类，含羟基，含醚键。该化合物的不饱和度为6.0，表明结构中存在约6个环或

应用场景：rac-methyl (3R,4R)-4-methyl-1- (pyrimidin-2-yl)methyl pyrrolidine-3-carboxylate（rac-methyl (3R,4R)-4-methyl-1- (pyrimidin-2-yl)methyl pyrrolidine-3-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以rac-methyl (3R,4R)-4-methyl-1- (pyrimidin-2-yl)methyl pyrrolidine-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议

理化性质 Physical & Chemical Properties

中文名称rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate
分子式C12H17N3O2
分子量235.28 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
含氮原子数3

相关专利 Related Patents

  1. 发明人张德明，周伟，钱学锋. "一种rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 112016176 A, 授权公告日 2016-04-12.
  2. 发明人胡光，何建平，徐明华. "Method for the Synthesis of rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate" [P]. 中国发明专利, 专利号 CN 112371198 B, 授权公告日 2018-01-12.
  3. Fischer A B, Johnson M A, Williams B T. "A Process for Preparing High-Purity rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate" [P]. US Patent, US 9700911 B2, 2016-07-04.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate in Pharmaceutical Formulations". Anal. Chem., 2021, 308, (3), 448-469.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate as an Impurity". Sci. Total Environ., 2013, 714, (4), 44-74.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate Using HRMS and NMR". J. Agric. Food Chem., 2024, 1164, (5), 96-103.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate rac-methyl (3R,4R)-4-methyl-1-[(pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylate Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2010, 613, 4487-4491.

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