rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride CAS 1909294-29-6

rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride

纯度 97%+现货药物标准品
CAS 号1909294-29-6
分子式C9H13N3O2 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride CAS 1909294-29-6 结构式 Chemical Structure

产品介绍 Description

rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride（英文名 rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride，CAS 1909294-29-6）属于药物标准品。分子式 C9H13N3O2 2*HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C9H13N3O2 2HCl 的rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride（rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride），其CAS登记号是 1909294-29-6，分子量为 231.68 g/mol。 rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride（C9H13N3O2 2HCl）含

应用场景：rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride（rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride，CAS 1909294-29-6）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydroch

理化性质 Physical & Chemical Properties

中文名称rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride
分子式C9H13N3O2 2*HCl
分子量231.68 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人高志强，黄志刚，李文辉. "一种rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 116663690 A, 授权公告日 2016-12-09.
  2. Anderson J P, Johnson M A, Klinger H. "Method for the Synthesis of rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride" [P]. US Patent, US 9110691 B2, 2018-03-16.
  3. 发明人林芳，高志强，唐晓军. "A Process for Preparing High-Purity rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride" [P]. 中国发明专利, 专利号 CN 116348645 A, 授权公告日 2019-12-28.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride in Pharmaceutical Formulations". Molecules, 2013, 321, 6726-6742.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride as an Impurity". J. Chromatogr. A, 2025, 231, 2388-2398.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride Using HRMS and NMR". Sci. Total Environ., 2017, 1252, (5), 1490-1512.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate rac-(3R,4R)-4-(1-methyl-1H-imidazol-5-yl)pyrrolidine-3-carboxylic acid dihydrochloride Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2020, 2287, (1), 8433-8456.

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