(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride CAS 1909310-05-9

(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride

纯度 97%+现货药物标准品
CAS 号1909310-05-9
分子式C12H17NO HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride (2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride CAS 1909310-05-9 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride（(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride，CAS 1909310-05-9），分子式 C12H17NO HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C12H17NO HCl 的(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride（(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride），其CAS登记号是 1909310-05-9，分子量为 227.73 g/mol。 从化学结构特征来看，(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代。该化合物的不饱和度为4.0，表明结构中存在约4个环或双键等价单元。分子

应用场景：针对化学分析用途，(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride（(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液

理化性质 Physical & Chemical Properties

中文名称(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride
分子式C12H17NO HCl
分子量227.73 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人冯建国，徐明华，刘建华. "一种(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 111100988 A, 授权公告日 2015-04-11.
  2. Patel M V, Davis P L, Thompson G K. "Method for the Synthesis of (2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride" [P]. US Patent, US 10184843 B2, 2022-05-28.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of (2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride in Pharmaceutical Formulations". Chromatographia, 2017, 988, 4343-4361.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of (2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride as an Impurity". J. Nat. Prod., 2010, 153, 6383-6400.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of (2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride Using HRMS and NMR". J. Pharm. Biomed. Anal., 2023, 598, (9), 5277-5297.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate (2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)methanamine hydrochloride Profile in Drug Substances According to ICH Guidelines". Food Chem., 2011, 747, 5709-5729.

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