tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate CAS 1909316-78-4

tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate

纯度 97%+现货药物标准品
CAS 号1909316-78-4
分子式C15H28N2O3
分子量284.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate CAS 1909316-78-4 结构式 Chemical Structure

产品介绍 Description

CAS 1909316-78-4 对应的tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate（tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C15H28N2O3，分子量 284.39。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括tert-butyl 4-(cyclopropylmethyl)amino-4-(hydroxymethyl)piperidine-1-carboxylate在内的目标物的控制。 tert-butyl 4-(cyclopropylmethyl)amino-4-(hydroxymethyl)piperidine-1-carboxylate（tert-butyl 4-(cyclopropylmethyl)amino-4-(hydroxymethyl)piperidine-1-carboxylate），CAS注册编号 1909316-78-4，化学分子式为 C15H28N2O3，分子量 284.39 g/mol。 从化学结构特征来看，tert-butyl 4-(cyclopropylmethyl)amino-4-(hydroxymethyl)piperidine-1-carboxylate的分子骨架中包含酰胺类，羧酸类，含羟基，含醚键。该化合物的不饱和度为3.0，表明结构中存在约3个环或双键等价单元。分子量为28

应用场景：tert-butyl 4- (cyclopropylmethyl)amino -4-(hydroxymethyl)piperidine-1-carboxylate（tert-butyl 4- (cyclopropylmethyl)amino -4-(hydroxymethyl)piperidine-1-carboxylate，CAS 1909316-78-4）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以tert-butyl 4- (cyclopropylmethyl)amino -4-(hydroxymethyl)piperidine-1-carboxylate配制标准系列工作溶

理化性质 Physical & Chemical Properties

中文名称tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate
分子式C15H28N2O3
分子量284.39 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1995年
含氮原子数2

相关专利 Related Patents

  1. 发明人孙丽萍，刘建华，钱学锋. "一种tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 112300522 B, 授权公告日 2015-11-25.
  2. O'Brien P Q, Mueller T, Stevens L M. "Method for the Synthesis of tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate" [P]. US Patent, US 10406778 B2, 2021-09-13.
  3. 发明人王建平，何建平，罗永刚. "A Process for Preparing High-Purity tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 115322162 B, 授权公告日 2019-03-05.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate in Pharmaceutical Formulations". Anal. Chim. Acta, 2024, 1841, 3885-3904.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate as an Impurity". J. Nat. Prod., 2017, 486, (6), 1647-1672.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of tert-butyl 4-[(cyclopropylmethyl)amino]-4-(hydroxymethyl)piperidine-1-carboxylate Using HRMS and NMR". Environ. Sci. Technol., 2023, 506, (8), 3802-3809.

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