4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride CAS 1909318-66-6

4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride

纯度 97%+现货药物标准品
CAS 号1909318-66-6
分子式C12H19N3O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride 4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride CAS 1909318-66-6 结构式 Chemical Structure

产品介绍 Description

CAS 1909318-66-6 对应的4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride（4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C12H19N3O HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

4-{3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-ylmethyl}piperidine hydrochloride的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1909318-66-6 对应的化合物4-{3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-ylmethyl}piperidine hydrochloride（英文标识 4-{3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-ylmethyl}piperidine hydrochloride），化学式 C12H19N3O HCl，相对分子质量 257.76。 从化学结构特征来看，4-{3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-ylmethyl}piperidine hydrochloride的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代。

应用场景：4-{ 3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl methyl}piperidine hydrochloride（4-{ 3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl methyl}piperidine hydrochloride，CAS 1909318-66-6）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以4-{ 3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl methyl}piperidine hydrochloride配制标准系列工作溶液，用

理化性质 Physical & Chemical Properties

中文名称4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride
分子式C12H19N3O HCl
分子量257.76 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人李文辉，沈红梅，朱建伟. "一种4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 111498943 A, 授权公告日 2023-07-25.
  2. Nowak P, Martínez F, Sørensen M. "Method for the Synthesis of 4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride" [P]. European Patent, EP 3248526 A1, 2020-10-21.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride in Pharmaceutical Formulations". Talanta, 2014, 2020, (11), 1636-1661.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride as an Impurity". J. Pharm. Biomed. Anal., 2020, 1187, (7), 8455-8458.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 4-{[3-(2-methylcyclopropyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine hydrochloride Using HRMS and NMR". Food Chem., 2011, 2295, (1), 8661-8676.

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