ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate CAS 1909319-42-1

ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate

纯度 97%+现货药物标准品
CAS 号1909319-42-1
分子式C16H17FN2O2
分子量288.32 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate CAS 1909319-42-1 结构式 Chemical Structure

产品介绍 Description

ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate（ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate，CAS 号 1909319-42-1）是 CATO 佳途自主生产的药物标准品，分子式 C16H17FN2O2，分子量 288.32。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylate（ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylate），CAS注册编号 1909319-42-1，化学分子式为 C16H17FN2O2，分子量 288.32 g/mol。 依据分子式为 C16H17FN2O2 的ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylate结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 288.32 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。由于碳链较长，脂溶性良好，该化合物在Octanol-Water分配系数测试中倾向于有机相。 推荐用于分析方法开发与验证，产品提供完整C

应用场景：针对化学分析用途，ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylate（ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法

理化性质 Physical & Chemical Properties

中文名称ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate
分子式C16H17FN2O2
分子量288.32 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. Fischer A B, Hughes D C, Yamamoto T. "一种ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate的合成方法" [P]. US Patent, US 10509424 B2, 2016-10-11.
  2. 发明人赵玉洁，何建平，王建平. "Method for the Synthesis of ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate" [P]. 中国发明专利, 专利号 CN 117337738 B, 授权公告日 2017-07-22.
  3. 发明人唐晓军，朱建伟，郑宇鹏. "A Process for Preparing High-Purity ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate" [P]. 中国发明专利, 专利号 CN 116565178 B, 授权公告日 2015-05-14.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2018, 632, (9), 4051-4065.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate as an Impurity". Chromatographia, 2015, 216, 1292-1321.

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