CAS 191930-58-2

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl Ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine 191930-58-2 7-O-[N-(4 inverted exclamation mark -Fluoresceincarbonyl)-L-alanyl] Taxol Flutax 1

纯度 97%+现货药物标准品
CAS 号191930-58-2
分子式C71H66N2O21
分子量1283.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl Ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine 191930-58-2 7-O-[N-(4 inverted exclamation mark -Fluoresceincarbonyl)-L-alanyl] Taxol Flutax 1 CAS 191930-58-2 结构式 Chemical Structure

产品介绍 Description

（(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl Ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine 191930-58-2 7-O-[N-(4 inverted exclamation mark -Fluoresceincarbonyl)-L-alanyl] Taxol Flutax 1）是药物分析与质量控制领域常用的药物标准品，CAS 号 191930-58-2。分子式 C71H66N2O21，分子量 1283.28。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括在内的目标物的控制。 CAS编号 191930-58-2 对应的化合物（英文标识 (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca3,4benz1,2-boxet-4-yl Ester N-(3',6'-dihydroxy-3-oxospiroisobenzofuran-1(3H),9'-9Hxanthen-5-yl)carbonyl-L-alanine 191930-58-2 7-O-N-(4 inverted exclamation mark -Fluorescei

应用场景：（(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9- (2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy -12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca 3,4 benz 1,2-b oxet-4-yl Ester N- (3',6'-dihydroxy-3-

理化性质 Physical & Chemical Properties

中文名称
分子式C71H66N2O21
分子量1283.28 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）40.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2011年
含氮原子数2

相关专利 Related Patents

  1. Thompson G K, Johnson M A, Williams B T. "一种的合成方法" [P]. US Patent, US 10204153 B2, 2017-02-15.
  2. 发明人马晓峰，郭海燕，刘建华. "Method for the Synthesis of (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl Ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine 191930-58-2 7-O-[N-(4 inverted exclamation mark -Fluoresceincarbonyl)-L-alanyl] Taxol Flutax 1" [P]. 中国发明专利, 专利号 CN 112609804 B, 授权公告日 2018-05-06.
  3. 发明人高志强，陈志强，沈红梅. "A Process for Preparing High-Purity (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl Ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine 191930-58-2 7-O-[N-(4 inverted exclamation mark -Fluoresceincarbonyl)-L-alanyl] Taxol Flutax 1" [P]. 中国发明专利, 专利号 CN 110458626 B, 授权公告日 2021-02-28.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Agric. Food Chem., 2024, 985, 8482-8503.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Sep. Sci., 2020, 2107, 3171-3192.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl Ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine 191930-58-2 7-O-[N-(4 inverted exclamation mark -Fluoresceincarbonyl)-L-alanyl] Taxol Flutax 1 Using HRMS and NMR". Environ. Sci. Technol., 2024, 2300, (9), 982-999.

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