2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride CAS 1955494-60-6

2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride

纯度 97%+现货药物标准品
CAS 号1955494-60-6
分子式C6H9N3O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride 2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride CAS 1955494-60-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride（2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride）为药物标准品，CAS 登记号 1955494-60-6，分子式 C6H9N3O 2*HCl。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

与同类药物标准品相比，2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride的分子量为175.62 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C6H9N3O 2HCl 的2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride（2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride），其CAS登记号是 1955494-60-6，分子量为 175.62 g/mol。 受分子结构中酰胺类，含羟基，含醚键，含氯取代的影响，2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride表现为白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）。其固体形态的物理化学属性——包括175.62 g/mol的分子量——对于选择合适的样

应用场景：从实际应用出发，2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride（CAS 1955494-60-6）在化学分析中作为关键的基准对照物质。 推荐以2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/

理化性质 Physical & Chemical Properties

中文名称2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride
分子式C6H9N3O 2*HCl
分子量175.62 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1996年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人林芳，郑宇鹏，韩伟. "一种2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 113538167 A, 授权公告日 2024-05-19.
  2. 发明人林芳，杨光，张德明. "Method for the Synthesis of 2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride" [P]. 中国发明专利, 专利号 CN 108988506 A, 授权公告日 2016-10-19.
  3. Lee S K, Klinger H, Anderson J P. "A Process for Preparing High-Purity 2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride" [P]. US Patent, US 9092328 B2, 2024-11-02.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2024, 1613, 8060-8063.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride as an Impurity". Phytochemistry, 2011, 192, (6), 4299-4328.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride Using HRMS and NMR". J. Chromatogr. A, 2010, 1575, (11), 5462-5491.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 2-(aminomethyl)-6-methyl-3,4-dihydropyrimidin-4-one dihydrochloride Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2013, 717, (11), 5977-5999.

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