1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid CAS 1955524-20-5

1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1955524-20-5
分子式C13H20N4O4
分子量296.32 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid CAS 1955524-20-5 结构式 Chemical Structure

产品介绍 Description

1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid（1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid，CAS 号 1955524-20-5）是 CATO 佳途自主生产的药物标准品，分子式 C13H20N4O4，分子量 296.32。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

1-{1-(tert-butoxy)carbonylpiperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 1-{1-(tert-butoxy)carbonylpiperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid（1-{1-(tert-butoxy)carbonylpiperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid），CAS注册编号 1955524-20-5，化学分子式为 C13H20N4O4，分子量 296.32 g/mol。 从化学结构特征来看，1-{1-(tert-butoxy)carbonylpiperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键。该化合物的不饱和度为6.0，表明结构中存

应用场景：针对化学分析用途，1-{1- (tert-butoxy)carbonyl piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid（1-{1- (tert-butoxy)carbonyl piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以1-{1- (tert-butoxy)carbonyl piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议

理化性质 Physical & Chemical Properties

中文名称1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid
分子式C13H20N4O4
分子量296.32 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
含氮原子数4

相关专利 Related Patents

  1. 发明人沈红梅，郑宇鹏，黄志刚. "一种1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 113100653 B, 授权公告日 2015-08-24.
  2. Schröder R, Johansson L, Martínez F. "Method for the Synthesis of 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid" [P]. European Patent, EP 3170197 A1, 2025-04-13.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2019, 954, 9636-9642.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid as an Impurity". J. Pharm. Biomed. Anal., 2014, 718, 3680-3694.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid Using HRMS and NMR". Molecules, 2012, 1761, (3), 2799-2827.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-1,2,3-triazole-5-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2017, 1176, (2), 3313-3340.

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