3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride CAS 1955548-28-3

3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号1955548-28-3
分子式C12H15N3O3 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride 3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride CAS 1955548-28-3 结构式 Chemical Structure

产品介绍 Description

CAS 1955548-28-3 对应的3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride（3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C12H15N3O3 HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，3-2-(dimethylamino)ethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride的分子量为285.73 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 3-2-(dimethylamino)ethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride（3-2-(dimethylamino)ethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride），CAS注册编号 1955548-28-3，化学分子式为 C12H15N3O3 HCl，分子量 285.73 g/mol。 3-2-(dimethylamino)ethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydro

应用场景：从实际应用出发，3- 2-(dimethylamino)ethyl -2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride（CAS 1955548-28-3）在化学分析中作为关键的基准对照物质。 推荐以3- 2-(dimethylamino)ethyl -2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度

理化性质 Physical & Chemical Properties

中文名称3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride
分子式C12H15N3O3 HCl
分子量285.73 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. Park J H, Stevens L M, Yamamoto T. "一种3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride的合成方法" [P]. US Patent, US 10603961 B2, 2021-11-09.
  2. 发明人胡光，周伟，李文辉. "Method for the Synthesis of 3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride" [P]. 中国发明专利, 专利号 CN 112724512 A, 授权公告日 2019-04-22.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride in Pharmaceutical Formulations". Anal. Chem., 2021, 2046, 9041-9067.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride as an Impurity". Environ. Sci. Technol., 2015, 1665, 9564-9570.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of 3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylic acid hydrochloride Using HRMS and NMR". Talanta, 2022, 577, (2), 9211-9229.

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