2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride CAS 1955548-55-6

2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1955548-55-6
分子式C8H11ClN2S 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride 2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride CAS 1955548-55-6 结构式 Chemical Structure

产品介绍 Description

CAS 1955548-55-6 对应的2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride（2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C8H11ClN2S 2*HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 化学式为 C8H11ClN2S 2HCl 的2-(chloromethyl)-5-methyl-4H,5H,6H,7H-1,3thiazolo5,4-cpyridine dihydrochloride（2-(chloromethyl)-5-methyl-4H,5H,6H,7H-1,3thiazolo5,4-cpyridine dihydrochloride），其CAS登记号是 1955548-55-6，分子量为 239.16 g/mol。 依据分子式为 C8H11ClN2S 2HCl 的2-(chloromethyl)-5-methyl-4H,5H,6H,7H-1,3thiazolo5,4-cpyridine dihydrochloride结构特征，其分子内含含氰基，含硫有机，含氯取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 239.16 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参

应用场景：从实际应用出发，2-(chloromethyl)-5-methyl-4H,5H,6H,7H- 1,3 thiazolo 5,4-c pyridine dihydrochloride（CAS 1955548-55-6）在化学分析中作为关键的基准对照物质。 推荐以2-(chloromethyl)-5-methyl-4H,5H,6H,7H- 1,3 thiazolo 5,4-c pyridine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室

理化性质 Physical & Chemical Properties

中文名称2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride
分子式C8H11ClN2S 2*HCl
分子量239.16 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1996年
卤素含量Cl取代
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. Nielsen H, Martínez F, Johansson L. "一种2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride的合成方法" [P]. European Patent, EP 3115632 A1, 2015-08-16.
  2. Sørensen M, Lefèvre J P, Björnsson E. "Method for the Synthesis of 2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride" [P]. European Patent, EP 3344215 A1, 2015-10-20.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2020, 691, (11), 7780-7787.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride as an Impurity". Environ. Sci. Technol., 2012, 345, (4), 3831-3859.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride Using HRMS and NMR". Chemosphere, 2010, 2423, (8), 2578-2601.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 2-(chloromethyl)-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine dihydrochloride Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2025, 785, 2113-2132.

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