rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid CAS 1969287-86-2

rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1969287-86-2
分子式C12H17N3O3
分子量251.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid CAS 1969287-86-2 结构式 Chemical Structure

产品介绍 Description

rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid（rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid，CAS 号 1969287-86-2）是 CATO 佳途自主生产的药物标准品，分子式 C12H17N3O3，分子量 251.28。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 1969287-86-2 对应的化合物rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid（英文标识 rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid），化学式 C12H17N3O3，相对分子质量 251.28。 rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid（C12H17N3O3）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光

应用场景：从实际应用出发，rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid（CAS 1969287-86-2）在化学分析中作为关键的基准对照物质。 推荐以rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样

理化性质 Physical & Chemical Properties

中文名称rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid
分子式C12H17N3O3
分子量251.28 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
含氮原子数3

相关专利 Related Patents

  1. Martínez F, Björnsson E, Mueller T C. "一种rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid的合成方法" [P]. European Patent, EP 3886822 A1, 2022-10-14.
  2. Lefèvre J P, Mueller T C, Rossi M. "Method for the Synthesis of rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid" [P]. European Patent, EP 3265265 A1, 2023-11-08.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid in Pharmaceutical Formulations". J. Nat. Prod., 2011, 964, 5115-5142.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid as an Impurity". Food Chem., 2012, 484, (10), 4541-4550.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid Using HRMS and NMR". Phytochemistry, 2012, 1122, (6), 2368-2392.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate rac-(2R,3R)-1-ethyl-2-(1-methyl-1H-imidazol-2-yl)-6-oxopiperidine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2024, 350, (1), 776-795.

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