rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid CAS 1969288-12-7

rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1969288-12-7
分子式C12H13NO4
分子量235.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid CAS 1969288-12-7 结构式 Chemical Structure

产品介绍 Description

rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid（英文名 rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid，CAS 1969288-12-7）属于药物标准品。分子式 C12H13NO4，分子量 235.24。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid在内的目标物的控制。 CAS编号 1969288-12-7 对应的化合物rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid（英文标识 rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid），化学式 C12H13NO4，相对分子质量 235.24。 从化学结构特征来看，rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid的分子骨架中包含氨基酸衍生物，酰胺类，含羟基，含醚键。该化合物的不饱和度为7.0，表明结构中存在约7个环或双键等价单元。分子量为235.24 g/mol，

应用场景：rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid（rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid，CAS 1969288-12-7）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid
分子式C12H13NO4
分子量235.24 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
含氮原子数1

相关专利 Related Patents

  1. 发明人沈红梅，陈志强，林芳. "一种rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 112018567 A, 授权公告日 2016-04-02.
  2. 发明人杨光，林芳，马晓峰. "Method for the Synthesis of rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 109268959 B, 授权公告日 2015-01-08.
  3. 发明人黄志刚，朱建伟，冯建国. "A Process for Preparing High-Purity rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 108940650 A, 授权公告日 2018-08-09.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid in Pharmaceutical Formulations". Molecules, 2018, 1143, (1), 6595-6610.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid as an Impurity". Rapid Commun. Mass Spectrom., 2022, 1459, (12), 5119-5149.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid Using HRMS and NMR". Phytochemistry, 2013, 829, 2026-2042.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate rac-(2R,3S,4S)-4-hydroxy-1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Food Chem., 2011, 1433, 1338-1350.

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