rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid CAS 1969288-58-1

rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1969288-58-1
分子式C14H21N3O4
分子量295.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid CAS 1969288-58-1 结构式 Chemical Structure

产品介绍 Description

rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid（英文名 rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid，CAS 1969288-58-1）属于药物标准品。分子式 C14H21N3O4，分子量 295.33。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括rac-(3R,4S)-1-(tert-butoxy)carbonyl-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid在内的目标物的控制。 rac-(3R,4S)-1-(tert-butoxy)carbonyl-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid（rac-(3R,4S)-1-(tert-butoxy)carbonyl-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid），CAS注册编号 1969288-58-1，化学分子式为 C14H21N3O4，分子量 295.33 g/mol。 rac-(3R,4S)-1-(tert-butoxy)carbonyl-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid（C14H21N3O4）含有含氮杂

应用场景：从实际应用出发，rac-(3R,4S)-1- (tert-butoxy)carbonyl -4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid（CAS 1969288-58-1）在化学分析中作为关键的基准对照物质。 推荐以rac-(3R,4S)-1- (tert-butoxy)carbonyl -4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求

理化性质 Physical & Chemical Properties

中文名称rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid
分子式C14H21N3O4
分子量295.33 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
含氮原子数3

相关专利 Related Patents

  1. 发明人沈红梅，王建平，钱学锋. "一种rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 115903051 A, 授权公告日 2023-02-12.
  2. 发明人黄志刚，刘建华，罗永刚. "Method for the Synthesis of rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 113639158 B, 授权公告日 2023-12-02.
  3. Sørensen M, Schröder R, Martínez F. "A Process for Preparing High-Purity rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid" [P]. European Patent, EP 3381238 A1, 2024-10-01.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid in Pharmaceutical Formulations". Food Chem., 2021, 1813, (7), 1263-1266.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid as an Impurity". J. Sep. Sci., 2020, 1859, (1), 1464-1494.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid Using HRMS and NMR". Sci. Total Environ., 2010, 1562, 6724-6739.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate rac-(3R,4S)-1-[(tert-butoxy)carbonyl]-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2015, 722, (5), 1646-1663.

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