rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride CAS 1989638-19-8

rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1989638-19-8
分子式C9H15N3O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride CAS 1989638-19-8 结构式 Chemical Structure

产品介绍 Description

rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride（rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1989638-19-8。分子式 C9H15N3O 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括rac-(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-ylmethanamine dihydrochloride在内的目标物的控制。 CAS编号 1989638-19-8 对应的化合物rac-(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-ylmethanamine dihydrochloride（英文标识 rac-(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-ylmethanamine dihydrochloride），化学式 C9H15N3O 2HCl，相对分子质量 217.70。 从化学结构特征来看，rac-(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-ylmethanamine dihydrochloride的分子骨架中包含酰胺类，含羟基，含醚键，含氯取代。该化合物的不饱和度为3.0，表明结构中存在约3个环或双键等价单

应用场景：从实际应用出发，rac- (2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl methanamine dihydrochloride（CAS 1989638-19-8）在化学分析中作为关键的基准对照物质。 推荐以rac- (2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl methanamine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥

理化性质 Physical & Chemical Properties

中文名称rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride
分子式C9H15N3O 2*HCl
分子量217.70 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1996年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人黄志刚，周伟，孙丽萍. "一种rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 115013758 A, 授权公告日 2017-06-21.
  2. 发明人沈红梅，李文辉，朱建伟. "Method for the Synthesis of rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride" [P]. 中国发明专利, 专利号 CN 115317456 A, 授权公告日 2020-03-24.
  3. Mueller T, O'Brien P Q, Chen K W. "A Process for Preparing High-Purity rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride" [P]. US Patent, US 11271866 B2, 2024-10-08.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride in Pharmaceutical Formulations". Anal. Chim. Acta, 2019, 726, (12), 7340-7350.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride as an Impurity". Sci. Total Environ., 2014, 1601, (11), 24-41.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride Using HRMS and NMR". Talanta, 2015, 637, (5), 2807-2821.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate rac-[(2R,3S)-2-(1-methyl-1H-imidazol-2-yl)oxolan-3-yl]methanamine dihydrochloride Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2021, 1803, (10), 851-865.

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